Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MITF | O75030 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2552200 | 0.87 | ALDH1A1 (0.62) | SMN1; SMN2JAK2PAX8LMNAMAPT | |
| SCHEMBL2552921 | 0.86 | ALDH1A1 (0.61) | SMN1; SMN2JAK2PAX8LMNAMAPT | |
| SCHEMBL30771327 | 0.84 | GAA (0.57) | SMN1; SMN2JAK2PAX8LMNAMITF | |
| SCHEMBL12284224 | 0.84 | SMN1; SMN2 (0.65) | SMN1; SMN2JAK2PAX8LMNAMAPT | |
| SCHEMBL10502713 | 0.83 | GAA (0.52) | SMN1; SMN2JAK2PAX8LMNAMAPT | |
| SCHEMBL6320116 | 0.80 | SMN1; SMN2 (0.81) | SMN1; SMN2JAK2PAX8LMNAMAPT | |
| SCHEMBL4207828 | 0.79 | KDM4E (0.49) | SMN1; SMN2JAK2PAX8LMNAMITF | |
| SCHEMBL22323042 | 0.79 | ALDH1A1 (0.62) | SMN1; SMN2JAK2PAX8LMNAMAPT | |
| SCHEMBL21807155 | 0.79 | GAA (0.50) | SMN1; SMN2JAK2PAX8MITFHTT | |
| SCHEMBL15063194 | 0.79 | TSHR (0.62) | SMN1; SMN2LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| CN-1045597-C | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1999-10-13 | — | — | CN | disclosed |
| US-5852006-A | N-aminoalkyl-substituted nitrogen-containing six membered heterocyclic compounds | NIPPON CHEMIPHAR CO., LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0579169-B1 | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5574030-A | INHIBITING URINARY CONTRACTION, HETEROCYCLIC DIAMINES | NIPPON CHEMIPHAR CO., LTD. (JP) | 1996-11-12 | — | — | US | disclosed |
| CN-1092412-A | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1994-09-21 | — | — | CN | disclosed |
| EP-0579169-A1 | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |