Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.81 |
| ▸ | LMNA | P02545 | 9/20 | 0.81 |
| ▸ | MAPT | P10636 | 6/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.81 |
| ▸ | MITF | O75030 | 5/20 | 0.81 |
| ▸ | TP53 | P04637 | 4/20 | 0.81 |
| ▸ | ATM | Q13315 | 3/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.81 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.81 |
| ▸ | HTT | P42858 | 4/20 | 0.75 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.74 |
| ▸ | GFER | P55789 | 1/20 | 0.74 |
| ▸ | JAK2 | O60674 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12284224 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL6325548 | 0.86 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL6321267 | 0.85 | SMN1; SMN2 (0.94) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL10584214 | 0.84 | ALDH1A1 (0.97) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL24733386 | 0.82 | SMN1; SMN2 (0.81) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL9198947 | 0.80 | MAPT (0.75) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL2551775 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL7713764 | 0.78 | MAPT (0.77) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL7719197 | 0.78 | ALDH1A1 (0.71) | SMN1; SMN2LMNAMAPTALDH1A1MITF | |
| SCHEMBL28838516 | 0.77 | ALDH1A1 (0.56) | SMN1; SMN2LMNAMAPTALDH1A1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |