Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.48 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28913117 | 0.77 | JAK1 (0.48) | JAK2JAK1JAK3 | |
| SCHEMBL25519927 | 0.77 | JAK1 (0.48) | JAK2JAK1JAK3 | |
| SCHEMBL15262638 | 0.72 | EPHX1 (0.58) | EPHX1LMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2625568 | 0.72 | EPHX1 (0.58) | EPHX1LMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL17810262 | 0.71 | HPGDS (0.33) | ALDH1A1 | |
| SCHEMBL2625559 | 0.67 | EPHX1 (0.61) | EPHX1LMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2625555 | 0.67 | EPHX1 (0.67) | EPHX1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL23573335 | 0.66 | ALDH1A1 (0.56) | EPHX1LMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14654896 | 0.66 | EPHX1 (0.66) | EPHX1LMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL12521938 | 0.66 | EPHX2 (0.65) | EPHX1LMNAALDH1A1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142274-A1 | SUBSTITUTED ARYL COMPOUND | NANJING ZAIMING PHARMACEUTICAL CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| US-20230142274-A1 | SUBSTITUTED ARYL COMPOUND | NANJING ZAIMING PHARMACEUTICAL CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142274-A1 | SUBSTITUTED ARYL COMPOUND | RAD51, FANCI, BLM | MAPK8 1369/4885MAPK9 910/4885MAPK10 1143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.