Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 7/20 | 0.41 |
| ▸ | FLT3 | P36888 | 7/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22998319 | 0.85 | ULK1 (0.44) | ULK1KITFLT3MAPK3CDK2 | |
| SCHEMBL25522696 | 0.82 | ULK1 (0.55) | ULK1MAPK3CDK2KDRMAPK1 | |
| SCHEMBL30397931 | 0.79 | CDK2 (0.41) | ULK1MAPK3CDK2KDRMAPK1 | |
| SCHEMBL25218005 | 0.79 | CDK2 (0.41) | ULK1MAPK3CDK2KDRMAPK1 | |
| SCHEMBL25224397 | 0.78 | CDK2 (0.40) | ULK1MAPK8MAPK9MAPK3CDK2 | |
| SCHEMBL30397298 | 0.78 | CDK2 (0.40) | ULK1MAPK8MAPK9MAPK3CDK2 | |
| SCHEMBL25531402 | 0.77 | ULK1 (0.49) | ULK1MAPK8MAPK9MAPK3CDK2 | |
| SCHEMBL30397492 | 0.77 | ULK1 (0.49) | ULK1MAPK8MAPK9MAPK3CDK2 | |
| SCHEMBL30397992 | 0.77 | MAPK3 (0.46) | ULK1MAPK8MAPK3CDK2KDR | |
| SCHEMBL30397130 | 0.77 | MAPK3 (0.46) | ULK1MAPK8MAPK3CDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111918863-B | Heterocyclic compounds | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |
| CN-111918863-A | Heterocyclic compounds | 武田药品工业株式会社 | 2020-11-10 | — | — | CN | disclosed |