Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2546393 | 0.89 | L3MBTL1 (0.51) | L3MBTL1TDP1ATMPTGESNPSR1 | |
| SCHEMBL11349580 | 0.81 | L3MBTL1 (0.41) | L3MBTL1TDP1ATMPTGESNPSR1 | |
| SCHEMBL4654046 | 0.79 | NPSR1 (0.43) | L3MBTL1TDP1ATMNPSR1RAB9A | |
| SCHEMBL11297916 | 0.79 | NPSR1 (0.43) | L3MBTL1TDP1ATMNPSR1RAB9A | |
| SCHEMBL9366366 | 0.76 | TDP1 (0.52) | L3MBTL1TDP1ATMPTGESNPSR1 | |
| SCHEMBL9353496 | 0.76 | ALDH1A1 (0.41) | L3MBTL1TDP1ATMNPSR1RAB9A | |
| SCHEMBL867886 | 0.75 | L3MBTL1 (1.00) | L3MBTL1TDP1ATMPTGESNPSR1 | |
| SCHEMBL10871503 | 0.75 | L3MBTL1 (0.70) | L3MBTL1TDP1ATMPTGESNPSR1 | |
| SCHEMBL11094305 | 0.75 | TDP1 (0.46) | L3MBTL1TDP1ATMPTGESNPSR1 | |
| SCHEMBL11263580 | 0.74 | POLB (0.43) | L3MBTL1TDP1ATMNPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660469-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO 'B, F! '1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | Helm AG (DE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005012274-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO `B, F! `1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2005-02-10 | — | — | WO | claimed |
| CN-103788014-A | Preparation methods of 10 H-dibenzo[b,f][1,4]thiazepin-11-one and quetiapine | ANHUI ANTENG PHARMACEUTICAL CO LTD | 2014-05-14 | — | — | CN | disclosed |
| WO-2011121602-A1 | PROCESS FOR PREPARATION OF DIBENZOTHIAZEPINONE COMPOUNDS | HIKAL LIMITED (IN) | 2011-10-06 | — | — | WO | disclosed |
| EP-1660469-B1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO 'B, F! '1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2007-08-29 | — | — | EP | disclosed |
| EP-1660469-B1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO 'B, F! '1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2007-08-29 | — | — | EP | disclosed |
| WO-2007004234-A1 | A PROCESS FOR THE PREPARATION OF 2-[2-(4-DIBENZO[b,f] [L,4] THIAZEPIN-11-yl-1- PIPERAZINYL)ETHOXY] ETHANOL FUMARATE | USV LIMITED (IN) | 2007-01-11 | — | — | WO | disclosed |
| EP-1660469-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO 'B, F! '1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | Helm AG (DE) | 2006-05-31 | — | — | EP | disclosed |
| EP-1660469-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO 'B, F! '1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | Helm AG (DE) | 2006-05-31 | — | — | EP | disclosed |
| CN-1239487-C | Internediate for preparing quetiapin and preparation method of the intermediate | EGIS GYOGYSZERGYAR RESZVENYTAR (HU) | 2006-02-01 | — | — | CN | disclosed |
| WO-2005012274-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO `B, F! `1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012274-A1 | PROCESS FOR THE PREPARATION OF 11-(1-PIPERAZINYL)DIBENZO `B, F! `1 ,4!-THIAZEPINE, AN INTERMEDIATE IN THE SYNTHESIS OF THE ANTIPSYCHOTIC DRUG QUETIAPINE | HELM AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| CN-1177839-C | Preparation method of quetiapine and intermediate thereof | ����˹ҩ�﹤�� | 2004-12-01 | — | — | CN | disclosed |
| CN-1537847-A | Internediate for preparing quetiapin and preparation method of the intermediate | ����˹ҩ�﹤�� | 2004-10-20 | — | — | CN | disclosed |
| CN-1396916-A | Preparation method of quetiapine and intermediate thereof | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-02-12 | — | — | CN | disclosed |
| EP-0240228-B1 | THIAZEPINE COMPOUNDS | ICI AMERICAS INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| EP-0240228-A1 | Thiazepine compounds | ICI AMERICAS INC. (US) | 1987-10-07 | — | — | EP | disclosed |