Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20541910 | 0.98 | HIF1A (0.56) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL20541756 | 0.98 | HIF1A (0.56) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL4207555 | 0.98 | HIF1A (0.56) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL17501903 | 0.98 | HIF1A (0.56) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL18729719 | 0.98 | HIF1A (0.56) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL22265893 | 0.98 | HIF1A (0.56) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL20541311 | 0.98 | HIF1A (0.56) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL23883184 | 0.96 | HIF1A (0.54) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Bromide SCHEMBL2552373 | 0.96 | HIF1A (0.54) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL30872528 | 0.96 | HIF1A (0.54) | HIF1AHRH1HTR2ACHRNA7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170182170-A1 | Nitric Oxide Donors | MEDICAL RESEARCH COUNCIL (GB) | 2017-06-29 | — | — | US | disclosed |
| US-9629859-B2 | Nitric oxide donors | MEDICAL RESEARCH COUNCIL (NZ) | 2017-04-25 | — | — | US | disclosed |
| US-20150250804-A1 | Nitric Oxide Donors | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2015-09-10 | — | — | US | disclosed |
| US-9045505-B2 | Nitric oxide donors | UNIVERSITY OF OTAGO (NZ) | 2015-06-02 | — | — | US | disclosed |
| CN-103068407-A | Lipophilic cationic probe for pet- imaging | MEDICAL RES COUNCIL | 2013-04-24 | — | — | CN | disclosed |
| US-20130064768-A1 | LIPOPHILIC CATIONIC PROBE FOR PET-IMAGING | MEDICAL RESEARCH COUNCIL (GB) | 2013-03-14 | — | — | US | disclosed |
| EP-2552494-A1 | LIPOPHILIC CATIONIC PROBE FOR PET- IMAGING | Medical Research Council (GB) | 2013-02-06 | — | — | EP | disclosed |
| EP-2066680-B1 | TRIPHENYLPHOSPHONIUM THIONITRITE NITRIC OXIDE DONORS | MEDICAL RES COUNCIL (GB) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011121276-A1 | LIPOPHILIC CATIONIC PROBE FOR PET- IMAGING | MEDICAL RESEARCH COUNCIL (GB) | 2011-10-06 | — | — | WO | disclosed |
| WO-2010110684-A1 | NITRIC OXIDE DONORS | SMITH ROBIN ANDREW JAMES (NZ) | 2010-09-30 | — | — | WO | disclosed |
| US-20100240615-A1 | NITRIC OXIDE DONORS | University of Orago (NZ) | 2010-09-23 | — | — | US | disclosed |
| US-20090233873-A1 | NITRIC OXIDE DONORS | UNIVERSITY OF OTAGO (NZ) | 2009-09-17 | — | — | US | disclosed |
| EP-2066680-A1 | TRIPHENYLPHOSPHONIUM THIONITRITE NITRIC OXIDE DONORS | MEDICAL RESEARCH COUNCIL (GB) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008039085-A1 | TRIPHENYLPHOSPHONIUM THIONITRITE NITRIC OXIDE DONORS | UNIVERSITY OF OTAGO (NZ) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250804-A1 | Nitric Oxide Donors | SQOR, ARG2, TXNRD2 | HIF1A 369/4885HRH1 4220/4885HTR2A 2371/4885 |
| US-20090233873-A1 | NITRIC OXIDE DONORS | SQOR, ARG2, TXNRD2 | HIF1A 369/4885HRH1 4220/4885HTR2A 2371/4885 |
| US-20100240615-A1 | NITRIC OXIDE DONORS | SQOR, ARG2, TXNRD2 | HIF1A 369/4885HRH1 4220/4885HTR2A 2371/4885 |
| US-20170182170-A1 | Nitric Oxide Donors | SQOR, ARG2, TXNRD2 | HIF1A 369/4885HRH1 4220/4885HTR2A 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.