SCHEMBL25525563

SCHEMBL25525563

COC(=O)c1ccc([C@H](C#N)CC(=O)c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.55
TSHR P16473 2/20 0.53
RAB9A P51151 5/20 0.52
ALDH1A1 P00352 4/20 0.52
MAPT P10636 4/20 0.52
NPC1 O15118 3/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
HPGD P15428 1/20 0.52
AGTR1 P30556 1/20 0.52
L3MBTL1 Q9Y468 4/20 0.49
TDP1 Q9NUW8 1/20 0.46
CASP3 P42574 1/20 0.44
SENP8 Q96LD8 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
SENP6 Q9GZR1 1/20 0.44
ROCK2 O75116 1/20 0.44
HSP90AA1 P07900 1/20 0.44
GAA P10253 1/20 0.44
HTT P42858 2/20 0.44
MAPK1 P28482 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8695606 1.00 KMT2A (0.55) KMT2ATSHRRAB9AALDH1A1MAPT
SCHEMBL6204424 0.84 L3MBTL1 (0.69) KMT2ARAB9AALDH1A1MAPTNPC1
SCHEMBL31326025 0.83 TSHR (0.53) KMT2ATSHRALDH1A1MAPTNPC1
SCHEMBL1754734 0.83 TSHR (0.53) KMT2ATSHRALDH1A1MAPTNPC1
SCHEMBL28727147 0.83 KMT2A (0.51) KMT2ATSHRALDH1A1MAPTNPC1
SCHEMBL25525517 0.82 KMT2A (0.53) KMT2ATSHRRAB9AALDH1A1MAPT
SCHEMBL28727138 0.82 KMT2A (0.53) KMT2ATSHRRAB9AALDH1A1MAPT
SCHEMBL8697129 0.82 KMT2A (0.53) KMT2ATSHRRAB9AALDH1A1MAPT
SCHEMBL8698087 0.82 L3MBTL1 (0.61) KMT2ARAB9AALDH1A1MAPTNPC1
SCHEMBL20504196 0.81 MAPT (0.46) KMT2ATSHRALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11661661-B2 Method for synthesizing beta-cyano ketone compound CHANGZHOU INSTITUTE OF TECHNOLOGY (CN) 2023-05-30 US disclosed