Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20580269 | 0.83 | CYP1A2 (0.66) | PDE4AMAPK1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1047810 | 0.80 | PDE4A (0.47) | PDE4AMAPK1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6245122 | 0.80 | KMT2A (0.55) | PDE4AMAPK1KMT2AALDH1A1KDM4E | |
| SCHEMBL23013504 | 0.79 | PDE4A (0.54) | PDE4AMAPK1SMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL21816315 | 0.79 | PDE4A (0.46) | PDE4AMAPK1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17492366 | 0.79 | PDE4A (1.00) | PDE4AMAPK1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL17492384 | 0.79 | PDE4A (0.76) | PDE4AMAPK1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL21816080 | 0.77 | KMT2A (0.60) | PDE4AMAPK1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14739475 | 0.76 | PDE4A (0.51) | PDE4AMAPK1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL23023734 | 0.76 | PDE4A (0.51) | PDE4AMAPK1SMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820766-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| US-20230242531-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-03 | — | — | US | disclosed |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242531-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | PDE4A 840/4885MAPK1 4069/4885KMT2A 2234/4885 |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | PDE4A 443/4885MAPK1 4389/4885KMT2A 1069/4885 |
| US-11820766-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | PDE4A 443/4885MAPK1 4389/4885KMT2A 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.