SCHEMBL25528539

SCHEMBL25528539

CC(=O)COc1cc(Cl)c(Cc2ccc(O)c(-c3cccc(C(C)=O)c3)c2)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
THRA P10827 9/20 0.50
THRB P10828 9/20 0.50
MAOB P27338 6/20 0.41
MAOA P21397 3/20 0.41
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23003706 0.93 THRA (0.60) THRATHRBMAOBMAOA
SCHEMBL25528552 0.92 THRA (0.48) THRATHRBMAOB
SCHEMBL23003784 0.91 THRA (0.48) THRATHRBMAOBMAOAMAPT
SCHEMBL25528562 0.89 THRA (0.52) THRATHRBMAOBMAOA
SCHEMBL25528529 0.89 THRA (0.46) THRATHRB
SCHEMBL25528523 0.88 THRA (0.51) THRATHRBMAOBMAPT
SCHEMBL25528706 0.88 THRA (0.57) THRATHRB
SCHEMBL25528534 0.88 THRA (0.50) THRATHRB
SCHEMBL25528524 0.88 THRA (0.51) THRATHRB
SCHEMBL25528533 0.88 THRA (0.51) THRATHRBMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11667606-B2 Thyromimetics AUTOBAHN THERAPEUTICS, INC. (US) 2023-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11667606-B2 Thyromimetics TPO, TSHR, TTR THRA 4/4885THRB 9/4885MAOB 450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.