SCHEMBL25528533

SCHEMBL25528533

COc1cccc(-c2cc(Cc3c(Cl)cc(OCC(C)=O)cc3Cl)ccc2O)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRA P10827 9/20 0.51
THRB P10828 9/20 0.51
PLA2G10 O15496 1/20 0.40
PLA2G2A P14555 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA1 P30542 1/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
LMNA P02545 1/20 0.39
CLK4 Q9HAZ1 2/20 0.39
CLK1 P49759 1/20 0.39
DYRK1A Q13627 1/20 0.39
MAOB P27338 1/20 0.39
PRKAB2 O43741 1/20 0.39
PRKAG1 P54619 1/20 0.39
PRKAA2 P54646 1/20 0.39
PRKAA1 Q13131 1/20 0.39
PRKAG3 Q9UGI9 1/20 0.39
PRKAG2 Q9UGJ0 1/20 0.39
PRKAB1 Q9Y478 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25528605 0.95 THRA (0.49) THRATHRBPLA2G10PLA2G2AADORA2A
SCHEMBL23003771 0.92 THRA (0.61) THRATHRBPLA2G10PLA2G2ALMNA
SCHEMBL25528034 0.91 THRB (0.50) THRATHRBPLA2G10PLA2G2AADORA2A
SCHEMBL25528562 0.89 THRA (0.52) THRATHRBPLA2G10PLA2G2AMAOB
SCHEMBL25528526 0.89 THRA (0.52) THRATHRBPLA2G10PLA2G2AMAOB
SCHEMBL25528523 0.88 THRA (0.51) THRATHRBPLA2G10PLA2G2AMAOB
SCHEMBL25528706 0.88 THRA (0.57) THRATHRBPLA2G10PLA2G2AADORA2A
SCHEMBL25528542 0.88 THRA (0.48) THRATHRBPLA2G10PLA2G2AMAOB
SCHEMBL25528524 0.88 THRA (0.51) THRATHRBPLA2G10PLA2G2A
SCHEMBL25528539 0.88 THRA (0.50) THRATHRBMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11667606-B2 Thyromimetics AUTOBAHN THERAPEUTICS, INC. (US) 2023-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11667606-B2 Thyromimetics TPO, TSHR, TTR THRA 4/4885THRB 9/4885PLA2G10 1397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.