Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 13/20 | 0.58 |
| ▸ | CDK2 | P24941 | 13/20 | 0.58 |
| ▸ | CCNK | O75909 | 11/20 | 0.58 |
| ▸ | CDK12 | Q9NYV4 | 11/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.58 |
| ▸ | CDK9 | P50750 | 8/20 | 0.58 |
| ▸ | ULK1 | O75385 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.49 |
| ▸ | CCND1 | P24385 | 2/20 | 0.49 |
| ▸ | CCND3 | P30281 | 2/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 7/20 | 0.47 |
| ▸ | CCNH | P51946 | 7/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25529569 | 0.78 | CCNK (0.57) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL21184419 | 0.75 | ULK1 (0.67) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL30204111 | 0.75 | CCNK (1.00) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL24839776 | 0.75 | CCNK (1.00) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL20421857 | 0.74 | CDK9 (0.77) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL20445253 | 0.74 | CDK9 (0.77) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL5567563 | 0.72 | ULK1 (0.65) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL20430303 | 0.72 | ULK1 (0.65) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL20430301 | 0.72 | ULK1 (0.65) | CCNE1CDK2CCNKCDK12CCNT1 | |
| SCHEMBL23838372 | 0.70 | CDK7 (0.64) | CDK2CCNKCDK12CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |