Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 7/20 | 0.42 |
| ▸ | ULK1 | O75385 | 6/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CCNK | O75909 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25530225 | 0.90 | ULK1 (0.37) | MAPK3ULK1PTK2PIK3C3ULK2 | |
| SCHEMBL25530170 | 0.79 | ULK1 (0.49) | MAPK3ULK1PTK2EGFRPIK3C3 | |
| SCHEMBL25531917 | 0.70 | ULK1 (0.46) | MAPK3ULK1PTK2PIK3C3ULK2 | |
| SCHEMBL25532521 | 0.69 | CCNK (0.51) | MAPK3ULK1PTK2PIK3C3CCNT1 | |
| SCHEMBL25526333 | 0.67 | ULK1 (0.48) | MAPK3ULK1PTK2PIK3C3CCNT1 | |
| SCHEMBL25209416 | 0.64 | GRM5 (0.38) | MAPK3ULK1PTK2CCNT1CCNK | |
| SCHEMBL30397703 | 0.64 | GRM5 (0.38) | MAPK3ULK1PTK2CCNT1CCNK | |
| SCHEMBL21184490 | 0.63 | ULK1 (0.63) | ULK1PTK2ULK2CCNT1CCNK | |
| SCHEMBL21184551 | 0.62 | ULK1 (0.62) | MAPK3ULK1PTK2PIK3C3ULK2 | |
| SCHEMBL17547443 | 0.62 | ULK1 (1.00) | ULK1ULK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |