Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 5/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CCNK | O75909 | 3/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25209416 | 1.00 | GRM5 (0.38) | GRM5CDK2CCNE1CCNKCDK12 | |
| SCHEMBL25218005 | 0.82 | CDK2 (0.41) | CDK2CCNE1CCNKCDK12CDK7 | |
| SCHEMBL30397931 | 0.82 | CDK2 (0.41) | CDK2CCNE1CCNKCDK12CDK7 | |
| SCHEMBL30397298 | 0.80 | CDK2 (0.40) | CDK2CCNE1CCNKCDK12CDK7 | |
| SCHEMBL25224397 | 0.80 | CDK2 (0.40) | CDK2CCNE1CCNKCDK12CDK7 | |
| SCHEMBL30397130 | 0.73 | MAPK3 (0.46) | CDK2CCNE1CCNKCDK12CDK7 | |
| SCHEMBL30397992 | 0.73 | MAPK3 (0.46) | CDK2CCNE1CCNKCDK12CDK7 | |
| SCHEMBL25530225 | 0.73 | ULK1 (0.37) | MAPK3MAPK1PTK2ULK1 | |
| SCHEMBL22998319 | 0.72 | ULK1 (0.44) | CDK2MAPK3MAPK1KDRPTK2 | |
| SCHEMBL25522696 | 0.71 | ULK1 (0.55) | CDK2CCNE1CCNKCDK12CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |