Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25531037 | 0.84 | HRH3 (0.41) | HRH3HDAC8HDAC6HDAC3ADRA2A | |
| SCHEMBL25541751 | 0.82 | HRH3 (0.40) | HRH3SIGMAR1HDAC8HDAC6HDAC3 | |
| SCHEMBL25531051 | 0.82 | SIGMAR1 (0.43) | SIGMAR1HDAC8HDAC6HDAC3KCNH2 | |
| SCHEMBL12203514 | 0.79 | HRH3 (0.61) | HRH3SIGMAR1HDAC8HDAC6KCNH2 | |
| SCHEMBL25531105 | 0.75 | SIGMAR1 (0.40) | SIGMAR1KCNH2ADRA2ACYP2D6ADRA2B | |
| SCHEMBL25531110 | 0.75 | SIGMAR1 (0.40) | SIGMAR1KCNH2ADRA2ACYP2D6ADRA2B | |
| SCHEMBL25530527 | 0.73 | HRH3 (0.48) | HRH3SIGMAR1HDAC8HDAC6KCNH2 | |
| SCHEMBL14587216 | 0.73 | CNR2 (0.53) | HRH3SIGMAR1KCNH2ADRA2ALMNA | |
| SCHEMBL25531108 | 0.71 | SIGMAR1 (0.41) | SIGMAR1KCNH2ADRA2ACYP2D6SLC6A2 | |
| SCHEMBL25531104 | 0.71 | SIGMAR1 (0.41) | SIGMAR1KCNH2ADRA2ACYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159491-A1 | Antimicrobial Compounds and Methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159491-A1 | Antimicrobial Compounds and Methods | MPO, NISCH, RPN2 | HRH3 2165/4885SIGMAR1 1380/4885HDAC8 1798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.