Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.33 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25533792 | 0.90 | IGF1R (0.36) | IRAK4EGLN2HCRTR1 | |
| SCHEMBL30398131 | 0.88 | CHRM2 (0.35) | HCRTR1 | |
| SCHEMBL25417681 | 0.78 | CCNK (0.48) | — | |
| SCHEMBL30397478 | 0.76 | SYK (0.39) | GPR119IRAK4HCRTR1TACR1 | |
| SCHEMBL25243408 | 0.76 | SYK (0.39) | GPR119IRAK4HCRTR1TACR1 | |
| SCHEMBL26126417 | 0.76 | MAPT (0.45) | GPR119MAPTHCRTR1TRPV1TACR1 | |
| SCHEMBL25234548 | 0.74 | USP30 (0.40) | GPR119MAPTTRPV1TACR1EGFR | |
| SCHEMBL25533413 | 0.74 | USP30 (0.40) | GPR119MAPTTRPV1TACR1EGFR | |
| SCHEMBL25517516 | 0.73 | DRD2 (0.43) | IRAK4 | |
| SCHEMBL25438402 | 0.73 | IDH1 (0.41) | MAPTHCRTR1TRPV1TACR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |