SCHEMBL30397478 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	SYK	P43405	4/20	0.39

▸	GPR119	Q8TDV5	4/20	0.38

▸	IRAK4	Q9NWZ3	2/20	0.38

▸	TACR1	P25103	1/20	0.36

▸	BRAF	P15056	1/20	0.36

▸	KDR	P35968	1/20	0.36

▸	HCRTR2	O43614	2/20	0.35

▸	HCRTR1	O43613	3/20	0.35

▸	USP30	Q70CQ3	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25243408	1.00	SYK (0.39)	SYKGPR119IRAK4TACR1BRAF
SCHEMBL25533413	0.78	USP30 (0.40)	SYKGPR119TACR1USP30
SCHEMBL25234548	0.78	USP30 (0.40)	SYKGPR119TACR1USP30
SCHEMBL25419655	0.77	IDH1 (0.41)	SYKTACR1HCRTR1USP30
SCHEMBL25438402	0.77	IDH1 (0.41)	SYKTACR1HCRTR1USP30
SCHEMBL25533403	0.77	IDH1 (0.41)	SYKTACR1HCRTR1USP30
SCHEMBL26126144	0.77	IRAK4 (0.48)	GPR119IRAK4HCRTR2HCRTR1
SCHEMBL26126417	0.77	MAPT (0.45)	SYKGPR119TACR1HCRTR1USP30
SCHEMBL25533466	0.76	GPR119 (0.38)	GPR119IRAK4TACR1HCRTR1
SCHEMBL28544531	0.71	USP30 (0.51)	SYKUSP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023091726-A1	INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12)	SYROS PHARMACEUTICALS, INC. (US)	2023-05-25	—	—	WO	disclosed