Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 5/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CCNH | P51946 | 2/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30398131 | 0.92 | CHRM2 (0.35) | IGF1RHCRTR1CCNKCDK12CHRM2 | |
| SCHEMBL25533466 | 0.90 | GPR119 (0.38) | HCRTR1EGLN2IRAK4 | |
| SCHEMBL25417681 | 0.81 | CCNK (0.48) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL30397353 | 0.75 | CCR6 (0.44) | HCRTR1CCR6 | |
| SCHEMBL30397120 | 0.70 | CDK7 (0.36) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL30397946 | 0.69 | CDK7 (0.38) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL30397422 | 0.68 | CCNK (0.34) | HCRTR1CCNKCDK12CDK7CCNH | |
| SCHEMBL30396777 | 0.68 | CCNK (0.39) | CCNKCDK12CDK7CCNHMNAT1 | |
| SCHEMBL25517516 | 0.67 | DRD2 (0.43) | IRAK4F2R | |
| SCHEMBL30397242 | 0.67 | DPP4 (0.38) | HCRTR1CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |