Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 10/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19347388 | 0.90 | PHGDH (0.47) | PHGDHTP53RXFP1LMNATHRB | |
| SCHEMBL25536810 | 0.88 | PHGDH (0.50) | PHGDHTP53RXFP1LMNATHRB | |
| SCHEMBL25536747 | 0.86 | PHGDH (0.49) | PHGDHTP53RXFP1LMNA | |
| SCHEMBL25536662 | 0.86 | PHGDH (0.67) | PHGDH | |
| SCHEMBL20794776 | 0.85 | PHGDH (0.61) | PHGDH | |
| SCHEMBL19347318 | 0.80 | PHGDH (0.56) | PHGDHTP53RXFP1LMNATHRB | |
| SCHEMBL20794375 | 0.79 | PHGDH (0.65) | PHGDHTP53RXFP1LMNATHRB | |
| SCHEMBL31008849 | 0.79 | PHGDH (0.65) | PHGDHTP53RXFP1LMNATHRB | |
| SCHEMBL26326966 | 0.77 | PHGDH (0.45) | PHGDHTP53RXFP1LMNATHRB | |
| SCHEMBL25538844 | 0.77 | PHGDH (0.57) | PHGDHTP53RXFP1THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426244-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |