Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 12/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25536747 | 0.91 | PHGDH (0.49) | PHGDHTP53RXFP1LMNA | |
| SCHEMBL19347388 | 0.82 | PHGDH (0.47) | PHGDHTP53RXFP1THRBSMN1; SMN2 | |
| SCHEMBL25536757 | 0.79 | PHGDH (0.57) | PHGDH | |
| SCHEMBL20768585 | 0.78 | PHGDH (0.58) | PHGDH | |
| SCHEMBL20768586 | 0.78 | PHGDH (0.58) | PHGDH | |
| SCHEMBL23393446 | 0.77 | PHGDH (0.45) | PHGDH | |
| SCHEMBL25536653 | 0.77 | PHGDH (0.51) | PHGDHTP53RXFP1THRBLMNA | |
| SCHEMBL20794390 | 0.76 | PHGDH (0.63) | PHGDH | |
| SCHEMBL19347499 | 0.75 | PHGDH (0.58) | PHGDH | |
| SCHEMBL19343129 | 0.73 | PHGDH (0.54) | PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234552-A2 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |