Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | FABP6 | P51161 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716923 | 0.88 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| SCHEMBL2555109 | 0.83 | KDM4E (0.48) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| SCHEMBL2547933 | 0.83 | KDM4E (0.48) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| SCHEMBL7716908 | 0.83 | KDM4E (0.48) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL2552429 | 0.82 | KDM4E (0.47) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL2552428 | 0.82 | KDM4E (0.47) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| SCHEMBL2551670 | 0.82 | HRH3 (0.47) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| SCHEMBL1134916 | 0.81 | KDM4E (0.50) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 | |
| SCHEMBL2555072 | 0.81 | KCNH2 (0.49) | SMN1; SMN2KCNH2HRH3ALDH1A1LMNA | |
| SCHEMBL2553562 | 0.81 | KDM4E (0.48) | SMN1; SMN2KDM4ERECQLKCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121309-A1 | PHENYL SULFONYL DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011121309-A1 | PHENYL SULFONYL DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-06 | — | — | WO | disclosed |