Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FABP6 | P51161 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553885 | 0.81 | SMN1; SMN2 (0.56) | KCNH2HRH3KMT2AMEN1ALDH1A1 | |
| SCHEMBL14819973 | 0.79 | ALDH1A1 (0.68) | HDAC4KMT2AMEN1POLBCTSL | |
| SCHEMBL2553125 | 0.76 | SMN1; SMN2 (0.47) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2549845 | 0.75 | HTR2A (0.67) | ALDH1A1 | |
| SCHEMBL2555154 | 0.72 | KDM4E (0.48) | KCNH2HRH3POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2547933 | 0.72 | KDM4E (0.48) | KCNH2HRH3POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7716908 | 0.72 | KDM4E (0.48) | KCNH2HRH3POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2555109 | 0.72 | KDM4E (0.48) | KCNH2HRH3POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7716923 | 0.71 | SMN1; SMN2 (0.54) | KCNH2HRH3KMT2AMEN1POLB | |
| SCHEMBL2551564 | 0.71 | HRH3 (0.45) | KCNH2HRH3POLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121309-A1 | PHENYL SULFONYL DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011121309-A1 | PHENYL SULFONYL DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-06 | — | — | WO | disclosed |