Proheptazine

Proheptazine

SCHEMBL25539

CCC(=O)OC1(c2ccccc2)CCCN(C)CC1C

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.84
DRD3 P35462 2/20 0.63
OPRM1 P35372 6/20 0.55
OPRD1 P41143 5/20 0.55
OPRK1 P41145 4/20 0.55
NPSR1 Q6W5P4 1/20 0.52
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
MAPK1 P28482 1/20 0.49
ALDH1A1 P00352 2/20 0.47
GAA P10253 1/20 0.44
SLC22A1 O15245 1/20 0.41
SLC6A4 P31645 1/20 0.41
ADRA1A P35348 1/20 0.41
KCNH2 Q12809 1/20 0.41
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betaprodine SCHEMBL25053 0.93 LMNA (0.97) LMNADRD3OPRM1OPRD1OPRK1
Betaprodine SCHEMBL186644 0.93 LMNA (0.97) LMNADRD3OPRM1OPRD1OPRK1
Betaprodine SCHEMBL248367 0.93 LMNA (0.97) LMNADRD3OPRM1OPRD1OPRK1
Alphaprodine SCHEMBL25054 0.93 LMNA (0.97) LMNADRD3OPRM1OPRD1OPRK1
Proheptazine SCHEMBL7618840 0.92 LMNA (0.72) LMNADRD3OPRM1OPRD1OPRK1
Betaprodine SCHEMBL394431 0.91 LMNA (1.00) LMNADRD3OPRM1OPRD1OPRK1
Alphaprodine SCHEMBL8818643 0.91 LMNA (1.00) LMNADRD3OPRM1OPRD1OPRK1
Betaprodine SCHEMBL1649307 0.90 LMNA (0.93) LMNADRD3OPRM1OPRD1OPRK1
SCHEMBL12369088 0.89 LMNA (0.67) LMNADRD3OPRM1OPRD1OPRK1
SCHEMBL12369092 0.88 LMNA (0.65) LMNADRD3OPRM1OPRD1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3512 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
US-20250319074-A1 TREATMENT AND MANAGEMENT OF AUGMENTATION IN RESTLESS LEGS SYNDROME UNIV EAST CAROLINA (US) 2025-10-16 US claimed
US-12383743-B2 Treatment of addiction and dependency TACA JR ARTURO C (US) 2025-08-12 US claimed
EP-4581017-A1 NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS Biodol Therapeutics (FR) 2025-07-09 EP claimed
WO-2024254056-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF CATALENT ONTARIO LIMITED (CA) 2024-12-12 WO claimed
US-12133922-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2024-11-05 US claimed
US-20240288374-A1 PLASMONIC NANOPARTICLE PLATFORM FOR ANALYTE DETECTION Zymeron Corporation 2024-08-29 US claimed
WO-2024172892-A1 PLASMONIC NANOPARTICLE PLATFORM FOR ANALYTE DETECTION Zymeron Corporation (US) 2024-08-22 WO claimed
US-12036192-B2 Combination treatments for opioid crisis PRESTI MICHAEL (US) 2024-07-16 US claimed
US-11964056-B1 Tamper resistant dosage forms PURDUE PHARMA L.P (US) 2024-04-23 US claimed
US-20020032581-A1 Single-patient drug trials used with accumulated database: risk of habituation OPT-E-SCRIP, INC. 2002-03-14 US claimed
WO-2002006826-A1 SINGLE-PATIENT DRUG TRIALS USED WITH ACCUMULATED DATABASE OPT-E-SCRIP, INC. (US) 2002-01-24 WO claimed
US-6335033-B2 SUSTAINED RELEASE EURO-CELTIQUE, S.A. (LU) 2002-01-01 US claimed
WO-2001080797-A1 MEDICATED WRAP HYSON MORTON I (US) 2001-11-01 WO claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-5965161-A SUSTAINED RELEASE ORAL UNIT DOSAGE FORM COMPRISING EXTRUDED NON-SPHEROIDAL PARTICLES OF AN OPIOID ANALGESIC IN A MATRIX OF RETARDANT(S) AND A WATER INSOLUBLE BINDER FORMED BY MIXING IN AN EXTRUDER, AND CUTTING EXTRUDED STRANDS INTO PARTICLES EURO-CELTIQUE, S.A. (LU) 1999-10-12 US claimed
CN-1130352-A Method for relieving pain by orally administering 24-hour sustained-release opioid dosage form capable of rapidly increasing initial blood concentration of patient EURO CELTIQUE SA (LU) 1996-09-04 CN claimed
US-4126684-A 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE CIBA-GEIGY CORPORATION (US) 1978-11-21 US claimed