Alphaprodine

Alphaprodine

SCHEMBL25054

CCC(=O)OC1(c2ccccc2)CCN(C)CC1C

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.97
DRD3 P35462 2/20 0.69
NPSR1 Q6W5P4 1/20 0.60
OPRM1 P35372 6/20 0.57
OPRD1 P41143 5/20 0.57
OPRK1 P41145 4/20 0.57
KMT2A Q03164 2/20 0.52
MEN1 O00255 1/20 0.52
MAPK1 P28482 1/20 0.51
ALDH1A1 P00352 2/20 0.49
GAA P10253 1/20 0.48
SLC22A1 O15245 1/20 0.46
SLC6A4 P31645 1/20 0.46
ADRA1A P35348 1/20 0.46
KCNH2 Q12809 1/20 0.46
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betaprodine SCHEMBL25053 1.00 LMNA (0.97) LMNADRD3NPSR1OPRM1OPRD1
Betaprodine SCHEMBL248367 1.00 LMNA (0.97) LMNADRD3NPSR1OPRM1OPRD1
Betaprodine SCHEMBL186644 1.00 LMNA (0.97) LMNADRD3NPSR1OPRM1OPRD1
Betaprodine SCHEMBL394431 0.99 LMNA (1.00) LMNADRD3NPSR1OPRM1OPRD1
Alphaprodine SCHEMBL8818643 0.99 LMNA (1.00) LMNADRD3NPSR1OPRM1OPRD1
Betaprodine SCHEMBL1649307 0.97 LMNA (0.93) LMNADRD3NPSR1OPRM1OPRD1
Proheptazine SCHEMBL25539 0.93 LMNA (0.84) LMNADRD3NPSR1OPRM1OPRD1
SCHEMBL11383571 0.89 LMNA (0.78) LMNADRD3NPSR1OPRM1OPRD1
Betaprodine SCHEMBL4283575 0.88 LMNA (0.77) LMNADRD3NPSR1OPRM1OPRD1
SCHEMBL8977860 0.88 LMNA (0.77) LMNADRD3NPSR1OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7746 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
US-20250319074-A1 TREATMENT AND MANAGEMENT OF AUGMENTATION IN RESTLESS LEGS SYNDROME UNIV EAST CAROLINA (US) 2025-10-16 US claimed
US-12383743-B2 Treatment of addiction and dependency TACA JR ARTURO C (US) 2025-08-12 US claimed
US-20250228771-A1 ALKALINE INTRAORAL PRODUCTS EMPLICURE AB (publ) (SE) 2025-07-17 US claimed
EP-4581017-A1 NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS Biodol Therapeutics (FR) 2025-07-09 EP claimed
EP-4565202-A1 ALKALINE INTRAORAL PRODUCTS EMPLICURE AB (publ) (SE) 2025-06-11 EP claimed
WO-2024254056-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF CATALENT ONTARIO LIMITED (CA) 2024-12-12 WO claimed
US-12133922-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2024-11-05 US claimed
US-12036192-B2 Combination treatments for opioid crisis PRESTI MICHAEL (US) 2024-07-16 US claimed
US-11964056-B1 Tamper resistant dosage forms PURDUE PHARMA L.P (US) 2024-04-23 US claimed
WO-1995014460-A1 OPIOID FORMULATIONS FOR TREATING PAIN EURO-CELTIQUE S.A. (LU) 1995-06-01 WO claimed
EP-0647448-A1 Orally administrable opioid formulations having extended duration of effect Euroceltique S.A. (LU) 1995-04-12 EP claimed
EP-0608893-A1 Inhibiting the development of tolerance to and/or dependence on an additive substance VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-08-03 EP claimed
US-5321012-A Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL COLLEGE (US) 1994-06-14 US claimed
EP-0415693-A1 Composition and method for selective enhancement of opiate activity and reduction of opiate tolerance and dependence ARIZONA TECHNOLOGY DEVELOPMENT CORPORATION (US) 1991-03-06 EP claimed
EP-0068838-B1 ANALGESIC PROCESS AND COMPOSITION THE UPJOHN COMPANY (US) 1986-09-17 EP claimed
US-4489080-A SYNERGISTIC COMBINATION OF NARCOTIC AND FLURBIPROFEN OR ESTER THE UPJOHN COMPANY (US) 1984-12-18 US claimed
US-4334526-A Method for administering a dissociative, unconscious type of anesthesia HAMACHER EDWARD N 1982-06-15 US claimed
US-4246894-A Method and system for administering a dissociative, unconscious type of anesthesia HAMACHER EDWARD N 1981-01-27 US claimed
US-4126684-A 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE CIBA-GEIGY CORPORATION (US) 1978-11-21 US claimed