Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554564 | 0.88 | MAOA (0.62) | RAB9ALMNAMAPTMEN1KMT2A | |
| SCHEMBL2554108 | 0.84 | KDM4E (0.63) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2555806 | 0.84 | KDM4E (0.63) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2554299 | 0.84 | ABL1 (0.67) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2558948 | 0.84 | KDM4E (0.63) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2556997 | 0.84 | KDM4E (0.63) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2557090 | 0.84 | KDM4E (0.63) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2562649 | 0.82 | KDM4E (0.58) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2559582 | 0.82 | KDM4E (0.86) | RAB9ALMNAKDM4EMAPTMEN1 | |
| SCHEMBL2553531 | 0.82 | KDM4E (0.61) | RAB9ALMNAKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |