SCHEMBL25544463

SCHEMBL25544463

N#Cc1cc(C#N)cc(-c2ccc(N(c3ccc(-c4ccncc4)cc3)c3ccc(-c4ccncc4)cc3)cc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CCNC P24863 1/20 0.41
CDK8 P49336 1/20 0.41
CYP11B2 P19099 1/20 0.39
LMNA P02545 1/20 0.38
PKN1 Q16512 1/20 0.38
PKN2 Q16513 1/20 0.38
CYP19A1 P11511 3/20 0.38
PIK3CD O00329 1/20 0.37
PIK3CA P42336 1/20 0.37
PIK3CB P42338 1/20 0.37
GSK3A P49840 2/20 0.37
GSK3B P49841 2/20 0.37
AURKA O14965 1/20 0.37
GCGR P47871 1/20 0.37
MAPK14 Q16539 1/20 0.37
LRRK2 Q5S007 1/20 0.36
FLT3 P36888 2/20 0.36
GRM5 P41594 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25543833 1.00 MAPT (0.44) MAPTSMN1; SMN2CCNCCDK8CYP11B2
SCHEMBL25543390 0.93 MAPT (0.44) MAPTSMN1; SMN2CCNCCDK8CYP11B2
SCHEMBL25544457 0.89 MMP3 (0.40) CYP19A1GRM5
SCHEMBL25543310 0.87 CYP11B2 (0.50) MAPTSMN1; SMN2CCNCCDK8CYP11B2
SCHEMBL25543818 0.87 CYP11B2 (0.50) MAPTSMN1; SMN2CCNCCDK8CYP11B2
SCHEMBL25544365 0.85 MMP3 (0.47) CYP11B2CYP19A1
SCHEMBL25544173 0.85 MMP3 (0.47) CYP11B2CYP19A1
SCHEMBL25543328 0.85 MMP3 (0.38) CYP19A1GRM5
SCHEMBL25543242 0.85 MMP3 (0.47) CYP11B2CYP19A1
SCHEMBL25543819 0.85 AURKA (0.51) CYP11B2GSK3AGSK3BAURKAGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230301181-A1 TERTIARY AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME LAPTO CO., LTD. (KR) 2023-09-21 US disclosed
US-20230301181-A1 TERTIARY AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME LAPTO CO., LTD. (KR) 2023-09-21 US disclosed
EP-4183784-A1 TERTIARY AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME Lapto Co., Ltd. (KR) 2023-05-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230301181-A1 TERTIARY AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME SAT1, FTO, SETDB1 MAPT 745/4885SMN1; SMN2 3067/4885CCNC 1766/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.