Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.63 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.45 |
| ▸ | RORA | P35398 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573355 | 0.79 | GPR119 (1.00) | GPR119HRH3 | |
| SCHEMBL2573353 | 0.79 | GPR119 (1.00) | GPR119HRH3 | |
| SCHEMBL22138868 | 0.79 | HRH3 (0.71) | GPR119HRH3FPR2PROKR1EPHX2 | |
| SCHEMBL5024491 | 0.79 | HRH3 (0.71) | GPR119HRH3FPR2PROKR1EPHX2 | |
| SCHEMBL229024 | 0.78 | HRH3 (1.00) | GPR119HRH3FPR2PROKR1RORA | |
| SCHEMBL14634277 | 0.77 | GPR119 (0.71) | GPR119HRH3FPR2PROKR1EPHX2 | |
| SCHEMBL2554612 | 0.77 | GPR119 (0.67) | GPR119HRH3EPHX2 | |
| SCHEMBL14634278 | 0.77 | GPR119 (0.71) | GPR119HRH3FPR2PROKR1EPHX2 | |
| SCHEMBL21004251 | 0.76 | SMN1; SMN2 (0.55) | HRH3FPR2PROKR1EPHX2 | |
| SCHEMBL21004332 | 0.76 | FPR2 (0.46) | HRH3FPR2PROKR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556056-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2013-02-13 | — | — | EP | claimed |
| EP-2556056-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127051-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-10-13 | — | — | WO | disclosed |