Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 2/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25546491 | 0.90 | FOLH1 (0.45) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL25546409 | 0.90 | SIRT6 (0.42) | FOLH1SIRT5SIRT6SIRT1SMN1; SMN2 | |
| SCHEMBL25546377 | 0.87 | SIRT6 (0.54) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL24170246 | 0.84 | FOLH1 (0.47) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL12055210 | 0.82 | KDM4E (0.48) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL16231519 | 0.82 | KDM4E (0.48) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL27423464 | 0.81 | FOLH1 (0.38) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL16231520 | 0.81 | FOLH1 (0.44) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL20756806 | 0.81 | SIRT6 (0.47) | FOLH1KDM4EMAPK1HIF1ASIRT5 | |
| SCHEMBL20235518 | 0.80 | SIRT5 (0.39) | FOLH1KDM4EMAPK1HIF1ASIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158150-A1 | COMPOUND COMPRISING A NUCLEIC ACID AND A HALF-LIFE EXTENSION MOTIF | NOVARTIS AG (CH) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158150-A1 | COMPOUND COMPRISING A NUCLEIC ACID AND A HALF-LIFE EXTENSION MOTIF | NSUN2, NSUN3, POLM | FOLH1 677/4885KDM4E 2196/4885MAPK1 4299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.