Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2552659 | 0.90 | AKR1B1 (0.47) | HTR2BHTR2CAKR1B1NLRP3TSHR | |
| SCHEMBL2551830 | 0.81 | AKR1B1 (0.38) | AKR1B1 | |
| SCHEMBL2548077 | 0.70 | AKR1B1 (0.51) | AKR1B1TSHR | |
| SCHEMBL11379499 | 0.68 | AKR1B1 (0.73) | AKR1B1TSHR | |
| SCHEMBL446093 | 0.66 | AKR1B1 (0.55) | AKR1B1TSHR | |
| SCHEMBL445570 | 0.65 | BACE1 (0.37) | — | |
| SCHEMBL11341929 | 0.64 | AKR1B1 (0.67) | AKR1B1TSHR | |
| SCHEMBL446794 | 0.63 | BACE1 (0.39) | AKR1B1LMNA | |
| SCHEMBL428953 | 0.62 | AKR1B1 (0.55) | AKR1B1TSHR | |
| SCHEMBL13732800 | 0.61 | XIAP (0.42) | HTR2BHTR2CMAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |