Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010420 | 0.77 | LMNA (0.44) | ADORA3ADORA2ATLR7TLR8ADORA1 | |
| SCHEMBL1058579 | 0.72 | ADORA3 (0.49) | ADORA3ADORA2ATLR7TLR8ADORA1 | |
| SCHEMBL1061480 | 0.69 | TLR8 (0.55) | TLR7TLR8 | |
| SCHEMBL1008810 | 0.68 | TLR7 (0.46) | ADORA3ADORA2ATLR7TLR8ADORA1 | |
| SCHEMBL832149 | 0.68 | BACE1 (0.58) | ADORA3KDM4ELMNAMAPTHTT | |
| SCHEMBL4278249 | 0.67 | KDM4E (0.49) | ADORA3KDM4EMEN1MITFLMNA | |
| SCHEMBL1010419 | 0.67 | TLR7 (0.44) | ADORA3ADORA2ATLR7TLR8ADORA1 | |
| SCHEMBL27764043 | 0.66 | KDM4E (0.38) | ADORA3ADORA2AKDM4ELMNAMAPT | |
| SCHEMBL1008620 | 0.66 | TLR7 (0.51) | ADORA3ADORA2ATLR7TLR8ADORA1 | |
| SCHEMBL1232719 | 0.66 | TLR7 (0.47) | ADORA3ADORA2ATLR7TLR8ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558069-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130379-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-20 | — | — | WO | disclosed |