Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703454 | 0.83 | TLR7 (0.52) | LMNALOXL2TLR7TLR8ADORA2A | |
| SCHEMBL1060527 | 0.83 | TLR7 (0.40) | LMNALOXL2TLR7TLR8ADORA2A | |
| SCHEMBL1924839 | 0.81 | TLR7 (0.48) | LMNALOXL2TLR7TLR8ADORA2A | |
| SCHEMBL1007693 | 0.78 | TLR7 (0.49) | LMNAKDM4ETLR7TLR8ADORA2A | |
| SCHEMBL2554832 | 0.77 | ADORA3 (0.40) | LMNAKDM4EMAPTTLR7TLR8 | |
| SCHEMBL2229462 | 0.75 | TLR7 (0.44) | LMNATLR7TLR8ADORA2AADRA1A | |
| SCHEMBL1062179 | 0.75 | BACE1 (0.49) | LMNAKDM4EMAPTTLR7TLR8 | |
| SCHEMBL1006096 | 0.74 | DCPS (0.54) | MAPTTLR7ADORA2AADORA3ADORA1 | |
| SCHEMBL1059574 | 0.73 | DHFR (0.53) | LMNAKDM4ETP53MAPTTSHR | |
| SCHEMBL1008890 | 0.73 | TLR7 (0.49) | LMNAKDM4ETP53MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268618-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2011-01-05 | — | — | EP | claimed |
| WO-2009111337-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2009-09-11 | — | — | WO | claimed |