Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042400 | 0.80 | NPSR1 (0.50) | ALOX15TSHRALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1703981 | 0.79 | ALDH1A1 (0.44) | TSHRALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL692996 | 0.79 | ALDH1A1 (0.48) | ALOX15TSHRALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL11842627 | 0.77 | ALDH1A1 (0.47) | ALOX15TSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1006640 | 0.77 | HTR3E (0.43) | TSHRALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL6129408 | 0.76 | ALDH1A1 (0.56) | ALOX15TSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3953896 | 0.74 | ALOX15 (0.44) | ALOX15TSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL18605308 | 0.74 | ALDH1A1 (0.44) | ALOX15TSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2096920 | 0.73 | NPSR1 (0.54) | ALOX15TSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11176346 | 0.73 | ALDH1A1 (0.43) | ALOX15TSHRALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558069-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130379-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-20 | — | — | WO | disclosed |