Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Nimorazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nimorazole SCHEMBL21836 | 0.87 | KMT2A (0.45) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2554643 | 0.87 | ALDH1A1 (0.48) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2549842 | 0.86 | GLA (0.46) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2555788 | 0.86 | POLB (0.44) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2555549 | 0.85 | KMT2A (0.38) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2558233 | 0.85 | KMT2A (0.38) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2555550 | 0.85 | KMT2A (0.38) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2552501 | 0.84 | GLA (0.43) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2552669 | 0.83 | MEN1 (0.40) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| Nimorazole SCHEMBL2556141 | 0.83 | PKM (0.43) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096123-A1 | RADIATION SENSITISER COMPOSITIONS | EUPHARMA PTY LTD (AU) | 2013-04-18 | — | — | US | claimed |
| EP-2558090-A1 | RADIATION SENSITISER COMPOSITIONS | Eupharma Pty Ltd (AU) | 2013-02-20 | — | — | EP | claimed |
| CN-102933213-A | Radiation sensitiser compositions | EUPHARMA PTY LTD | 2013-02-13 | — | — | CN | claimed |
| WO-2011127537-A1 | RADIATION SENSITISER COMPOSITIONS | PHEBRA PTY LTD (AU) | 2011-10-20 | — | — | WO | claimed |