Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25557074 | 1.00 | KCNH2 (0.40) | KCNH2CHRNA7SOS1CDK4CCND1 | |
| SCHEMBL22652209 | 0.81 | KCNH2 (0.37) | KCNH2CHRNA7 | |
| SCHEMBL26678178 | 0.81 | KCNH2 (0.37) | KCNH2CHRNA7 | |
| SCHEMBL25556995 | 0.80 | KCNH2 (0.43) | KCNH2CHRNA7CDK4CCND1JAK1 | |
| SCHEMBL25557072 | 0.77 | CHRNB2 (0.48) | — | |
| SCHEMBL25556992 | 0.77 | CHRNB2 (0.48) | — | |
| SCHEMBL22652110 | 0.76 | MAPT (0.38) | KCNH2CHRNA7 | |
| SCHEMBL26677915 | 0.76 | MAPT (0.38) | KCNH2CHRNA7 | |
| SCHEMBL14923977 | 0.74 | KCNH2 (0.52) | KCNH2CHRNA7CDK4CCND1 | |
| SCHEMBL26498536 | 0.72 | KCNH2 (0.46) | KCNH2CHRNA7JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |