Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652110 | 1.00 | MAPT (0.38) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL22652044 | 0.82 | ALDH1A1 (0.36) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL22652198 | 0.82 | ALDH1A1 (0.36) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL25208776 | 0.82 | AKR1C3 (0.35) | MAPTALDH1A1L3MBTL1MAPK1TDP1 | |
| SCHEMBL22652007 | 0.80 | KCNH2 (0.35) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL30411352 | 0.79 | HSD11B1 (0.45) | MAPTALDH1A1HSD11B1 | |
| SCHEMBL22652209 | 0.78 | KCNH2 (0.37) | KCNH2CHRNA7 | |
| SCHEMBL26678178 | 0.78 | KCNH2 (0.37) | KCNH2CHRNA7 | |
| SCHEMBL30900358 | 0.78 | TUBB4A (0.44) | MAPTALDH1A1SIRT6HSD11B1MAPK1 | |
| SCHEMBL11905273 | 0.78 | SIRT6 (0.44) | MAPTALDH1A1SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| EP-3966207-B1 | PHENYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS LLC (US) | 2023-11-01 | — | — | EP | disclosed |