Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 11/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652209 | 1.00 | KCNH2 (0.37) | KCNH2CHRNA7CHEK1ABL1PRKCB | |
| SCHEMBL25557074 | 0.81 | KCNH2 (0.40) | KCNH2CHRNA7 | |
| SCHEMBL25556993 | 0.81 | KCNH2 (0.40) | KCNH2CHRNA7 | |
| SCHEMBL25236239 | 0.79 | AKR1C3 (0.38) | — | |
| SCHEMBL25241300 | 0.79 | AKR1C3 (0.38) | — | |
| SCHEMBL26677915 | 0.78 | MAPT (0.38) | KCNH2CHRNA7 | |
| SCHEMBL22652110 | 0.78 | MAPT (0.38) | KCNH2CHRNA7 | |
| SCHEMBL22652078 | 0.78 | HSD11B1 (0.40) | KCNH2CHRNA7 | |
| SCHEMBL22652003 | 0.78 | HSD11B1 (0.40) | KCNH2CHRNA7 | |
| SCHEMBL14180539 | 0.78 | BRAF (0.41) | KCNH2CHRNA7BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| EP-3966207-B1 | PHENYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS LLC (US) | 2023-11-01 | — | — | EP | disclosed |