Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31733573 | 0.86 | PRKDC (0.44) | ERN1PRKDCENPP2G6PDIDE | |
| SCHEMBL7857418 | 0.81 | HTT (0.42) | ERN1PRKDCSMN1; SMN2PTGS2LMNA | |
| SCHEMBL26777577 | 0.80 | ALDH1A1 (0.41) | ERN1PRKDCSMN1; SMN2LMNA | |
| SCHEMBL20083904 | 0.80 | ERN1 (0.44) | ERN1ENPP2G6PDIDESMN1; SMN2 | |
| SCHEMBL136274 | 0.78 | ERN1 (0.53) | ERN1ENPP2 | |
| SCHEMBL21491267 | 0.78 | LMNA (0.51) | ERN1PTGS2LMNA | |
| SCHEMBL7752223 | 0.78 | PTGS2 (0.48) | ERN1PTGS2PTGS1 | |
| SCHEMBL12593470 | 0.76 | SMN1; SMN2 (0.52) | ERN1ENPP2G6PDIDESMN1; SMN2 | |
| SCHEMBL15814013 | 0.76 | ALDH1A1 (0.43) | ERN1ENPP2G6PDIDESMN1; SMN2 | |
| SCHEMBL7092074 | 0.76 | SMN1; SMN2 (0.61) | ERN1PRKDCSMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621135-B | LPA1 small molecule antagonist | 上海拓界生物医药科技有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-114621135-A | LPA1 small molecule antagonist | 上海拓界生物医药科技有限公司 | 2022-06-14 | — | — | CN | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |