Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255623 | 0.84 | MAPT (0.39) | ADRB2MAPTRAB9ANPC1LMNA | |
| SCHEMBL16986344 | 0.77 | ADRB2 (0.48) | ADRB2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL255621 | 0.75 | MEN1 (0.46) | MAPTRAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL16986357 | 0.74 | NPC1 (0.49) | ADRB2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL16287646 | 0.69 | NPC1 (0.45) | ADRB2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL16986338 | 0.69 | NPC1 (0.46) | ADRB2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL25495161 | 0.68 | MAPT (0.49) | ADRB2MAPTRAB9ANPC1LMNA | |
| SCHEMBL16146748 | 0.68 | RAB9A (0.47) | ADRB2MAPTRAB9ANPC1LMNA | |
| SCHEMBL2126846 | 0.67 | RAB9A (0.58) | ADRB2MAPTRAB9ANPC1LMNA | |
| SCHEMBL2454054 | 0.67 | RAB9A (0.58) | ADRB2MAPTRAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028756-A1 | PREPARATION OF SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE COMPOUNDS | INSTITUT QUÍMIC DE SARRIÀ CETS, FUNDACIÓ PRIVADA (ES) | 2012-03-08 | — | — | WO | disclosed |