Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 4/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532055 | 0.79 | SIK2 (0.45) | MAPK1FGFR1 | |
| SCHEMBL22612785 | 0.79 | SIK2 (0.45) | MAPK1FGFR1 | |
| SCHEMBL31532117 | 0.75 | CDK4 (0.40) | ALDH1A1KDRCDK4CCND1CDK2 | |
| SCHEMBL31532076 | 0.75 | CDK4 (0.42) | MEN1ALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL255623 | 0.75 | MAPT (0.39) | MEN1ALDH1A1GAAMAPTMAPK1 | |
| SCHEMBL255619 | 0.75 | ADRB2 (0.49) | MEN1ALDH1A1GAAMAPTMAPK1 | |
| SCHEMBL31532080 | 0.74 | MAPK14 (0.47) | ALDH1A1MAPTCDK4CCNA2CCND1 | |
| SCHEMBL15280148 | 0.73 | CDC7 (0.38) | ALDH1A1KDRFGFR1GSK3BROCK1 | |
| SCHEMBL29861753 | 0.72 | PDK2 (0.39) | MAPK1KDRFGFR1GSK3BROCK1 | |
| Ethane SCHEMBL5793409 | 0.70 | WEE1 (0.54) | FGFR1FGFR2FGFR4FGFR3WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028756-A1 | PREPARATION OF SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE COMPOUNDS | INSTITUT QUÍMIC DE SARRIÀ CETS, FUNDACIÓ PRIVADA (ES) | 2012-03-08 | — | — | WO | disclosed |