Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14252963 | 0.81 | TSHR (0.59) | TSHRATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28468524 | 0.76 | PTGS1 (0.45) | PTGS1PTGS2SLC22A12 | |
| SCHEMBL5632154 | 0.75 | TSHR (0.59) | TSHRATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27673212 | 0.75 | TSHR (0.59) | TSHRATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1631053 | 0.75 | TSHR (0.65) | TSHRATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23308872 | 0.75 | TSHR (0.59) | TSHRATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2104486 | 0.75 | TSHR (0.59) | TSHRATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20197168 | 0.74 | PTGS1 (0.48) | PTGS1PTGS2SLC22A12CA2 | |
| SCHEMBL18912216 | 0.74 | CNR1 (0.41) | KDM4EPTGS1PTGS2SLC22A12CA2 | |
| SCHEMBL30311835 | 0.74 | CNR1 (0.41) | KDM4EPTGS1PTGS2SLC22A12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108539270-B | Lithium secondary battery electrolyte and lithium secondary battery thereof | 广州天赐高新材料股份有限公司 | 2020-09-11 | — | — | CN | claimed |
| CN-111263760-A | Process for the preparation of 6- (2-hydroxy-2-methylpropoxy) -4- (6- (6- ((6-methoxypyridin-3-yl) methyl) -3, 6-diazabicyclo [3.1.1] hept-3-yl) pyridin-3-yl) pyrazolo [1, 5-a ] pyridine-3-carbonitrile | 奥瑞生物药品公司 | 2020-06-09 | — | — | CN | claimed |
| EP-4543446-A1 | SUBSTITUTED FUSED BICYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT | Alkermes, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023249872-A1 | SUBSTITUTED FUSED BICYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT | ALKERMES, INC. (US) | 2023-12-28 | — | — | WO | disclosed |
| CN-115916791-A | Crystalline RET inhibitors | 罗索肿瘤学公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-108539270-B | Lithium secondary battery electrolyte and lithium secondary battery thereof | 广州天赐高新材料股份有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111263760-A | Process for the preparation of 6- (2-hydroxy-2-methylpropoxy) -4- (6- (6- ((6-methoxypyridin-3-yl) methyl) -3, 6-diazabicyclo [3.1.1] hept-3-yl) pyridin-3-yl) pyrazolo [1, 5-a ] pyridine-3-carbonitrile | 奥瑞生物药品公司 | 2020-06-09 | — | — | CN | disclosed |
| US-10183015-B2 | Heterocyclic compounds and methods of use | MEDIVATION TECHNOLOGIES LLC (US) | 2019-01-22 | — | — | US | disclosed |
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |
| EP-2751076-B1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | MEDIMMUNE LTD (GB) | 2018-04-25 | — | — | EP | disclosed |
| US-20180028518-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES LLC | 2018-02-01 | — | — | US | disclosed |
| US-9102704-B2 | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines | SPIROGEN SARL (CH) | 2015-08-11 | — | — | US | disclosed |
| US-20150065519-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES LLC | 2015-03-05 | — | — | US | disclosed |
| US-20140275522-A1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | SPIROGEN SÁRL (CH) | 2014-09-18 | — | — | US | disclosed |
| US-8829184-B2 | Intermediates useful for the synthesis of pyrrolobenzodiazepines | SPIROGEN SARL (CH) | 2014-09-09 | — | — | US | disclosed |
| EP-2751076-A1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | Spirogen Sàrl (CH) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013053872-A1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | SPIROGEN SÀRL (CH) | 2013-04-18 | — | — | WO | disclosed |
| EP-2558445-A1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES | Spirogen Sàrl (CH) | 2013-02-20 | — | — | EP | disclosed |
| US-20130035484-A1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES | SPIROGEN DEVELOPMENTS SÀRL (CH) | 2013-02-07 | — | — | US | disclosed |
| WO-2011128650-A1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065519-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | HRAS, VHL, ESRRB | TSHR 114/4885ATM 1257/4885KDM4E 3356/4885 |
| US-20180028518-A1 | Heterocyclic Compounds and Methods of Use | LIPC, CPT1A, FABP1 | TSHR 3128/4885ATM 1319/4885KDM4E 2233/4885 |
| US-20140275522-A1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | ORC3, OXER1, SCO2 | TSHR 1536/4885ATM 3361/4885KDM4E 3002/4885 |
| US-10183015-B2 | Heterocyclic compounds and methods of use | LIPC, CPT1A, FABP1 | TSHR 3128/4885ATM 1319/4885KDM4E 2233/4885 |
| US-20130035484-A1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES | CYP11B2, CYP1B1, CYP11B1 | TSHR 1336/4885ATM 3383/4885KDM4E 2413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.