Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25566962 | 0.89 | ACHE (0.39) | ACHECHRM3CHRM2GAA | |
| SCHEMBL31091663 | 0.83 | CYP2D6 (0.42) | ACHECHRM3CHRM2GAADRD2 | |
| SCHEMBL25566734 | 0.82 | FUCA1 (0.42) | CHRM3CHRM2DRD2DRD4DRD3 | |
| SCHEMBL25566966 | 0.79 | CYP2D6 (0.42) | ACHECHRM3CHRM2GAA | |
| SCHEMBL25566965 | 0.79 | CHRM3 (0.43) | ACHECHRM3CHRM2GAA | |
| SCHEMBL25566963 | 0.79 | KDM1A (0.47) | CHRM3CHRM2DRD2DRD4DRD3 | |
| SCHEMBL29937437 | 0.74 | CHRM3 (0.41) | CHRM3CHRM2GAA | |
| SCHEMBL12881261 | 0.73 | DPP4 (0.41) | ACHECHRM2DRD2DRD4DRD3 | |
| SCHEMBL29344022 | 0.73 | KMT2A (0.43) | CHRM3CHRM2 | |
| SCHEMBL29937525 | 0.72 | CHRM3 (0.42) | ACHECHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4442686-A1 | KRAS INHIBITORS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd (CN) | 2024-10-09 | — | — | EP | disclosed |
| CN-118055932-A | KRAS inhibitor and preparation and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023098425-A1 | KRAS INHIBITORS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2023-06-08 | — | — | WO | disclosed |