Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25566966 | 0.87 | CYP2D6 (0.42) | CHRM3CHRM2ALDH1A1GAABCHE | |
| SCHEMBL25566734 | 0.85 | FUCA1 (0.42) | CHRM3CHRM2ALDH1A1 | |
| SCHEMBL25566962 | 0.80 | ACHE (0.39) | CHRM3CHRM2MEN1KMT2AALDH1A1 | |
| SCHEMBL25566963 | 0.80 | KDM1A (0.47) | CHRM3CHRM2 | |
| SCHEMBL25566735 | 0.79 | ACHE (0.38) | CHRM3CHRM2GAAACHE | |
| SCHEMBL29937525 | 0.79 | CHRM3 (0.42) | CHRM3CHRM2MEN1KMT2AALDH1A1 | |
| SCHEMBL29937437 | 0.78 | CHRM3 (0.41) | CHRM3CHRM2MEN1KMT2AALDH1A1 | |
| SCHEMBL31091663 | 0.77 | CYP2D6 (0.42) | CHRM3CHRM2MEN1KMT2ATSHR | |
| SCHEMBL29936728 | 0.72 | KMT2A (0.43) | CHRM3CHRM2KMT2AALDH1A1MAPT | |
| SCHEMBL29344022 | 0.72 | KMT2A (0.43) | CHRM3CHRM2KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4442686-A1 | KRAS INHIBITORS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd (CN) | 2024-10-09 | — | — | EP | disclosed |
| CN-118055932-A | KRAS inhibitor and preparation and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023098425-A1 | KRAS INHIBITORS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2023-06-08 | — | — | WO | disclosed |