Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25567190 | 0.81 | EGFR (0.49) | EGFRFLT3MAPK14MEN1NPC1 | |
| SCHEMBL25567124 | 0.74 | EGFR (0.46) | EGFRFLT3MAPK14MEN1NPC1 | |
| SCHEMBL25567722 | 0.70 | MAPK14 (0.46) | FLT3MAPK14MEN1NPC1RAB9A | |
| SCHEMBL25564759 | 0.70 | MAPK14 (0.58) | FLT3MAPK14MEN1NPC1RAB9A | |
| SCHEMBL14422913 | 0.70 | EGFR (0.72) | EGFRFLT3MAPK14MEN1NPC1 | |
| SCHEMBL4102589 | 0.69 | EGFR (0.74) | EGFRFLT3MAPK14MEN1NPC1 | |
| SCHEMBL25567562 | 0.68 | HPGD (0.47) | FLT3MAPK14MEN1NPC1RAB9A | |
| SCHEMBL14422912 | 0.68 | EGFR (0.68) | EGFRFLT3MAPK14MEN1NPC1 | |
| SCHEMBL4451956 | 0.67 | EGFR (1.00) | EGFRFLT3MAPK14MEN1NPC1 | |
| SCHEMBL4104287 | 0.66 | EGFR (0.70) | EGFRFLT3MAPK14MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078207-A1 | 6-POSITION-SUBSTITUTED INDOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 南京中医药大学 | 2023-05-11 | — | — | WO | disclosed |