Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16731504 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2STAT3ALDH1A1MEN1KMT2A | |
| SCHEMBL25255613 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL25567711 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2STAT3ALDH1A1MEN1KMT2A | |
| SCHEMBL1894478 | 0.81 | PTGS2 (0.44) | SMN1; SMN2STAT3ALDH1A1MEN1KMT2A | |
| SCHEMBL1006441 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2STAT3ALDH1A1MEN1KMT2A | |
| SCHEMBL16731505 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2STAT3PTGS2HTR6PTGIR | |
| SCHEMBL31329856 | 0.73 | CNR1 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL25567709 | 0.73 | CNR1 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL18019749 | 0.72 | RORC (0.45) | SMN1; SMN2ALDH1A1KMT2AMAPTL3MBTL1 | |
| SCHEMBL16731507 | 0.72 | BUB1 (0.47) | STAT3PTGS2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026762-A1 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-01-23 | — | — | US | disclosed |
| WO-2023101895-A1 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026762-A1 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GBA1, GBA2, UGCG | SMN1; SMN2 1330/4885STAT3 4699/4885ALDH1A1 2176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.