SCHEMBL2556774

SCHEMBL2556774

O=Cc1ccc(-c2cc(Cl)cc(C(=O)O)c2)cc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RXRA P19793 3/20 0.61
RXRB P28702 3/20 0.61
ALDH1A1 P00352 1/20 0.53
TPMT P51580 1/20 0.52
TRIM24 O15164 1/20 0.49
TRIM33 Q9UPN9 1/20 0.49
HCAR1 Q9BXC0 1/20 0.46
ERN1 O75460 4/20 0.44
HSD17B10 Q99714 1/20 0.44
DHODH Q02127 1/20 0.44
UNG P13051 1/20 0.43
CTRC Q99895 1/20 0.43
NOTUM Q6P988 1/20 0.42
LTB4R Q15722 1/20 0.40
AURKA O14965 1/20 0.39
TPX2 Q9ULW0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12607564 0.85 MAP4K4 (0.49) RXRARXRBALDH1A1ERN1HSD17B10
SCHEMBL2563676 0.83 TRIM24 (0.65) RXRARXRBALDH1A1TPMTTRIM24
SCHEMBL412577 0.82 HSD17B10 (0.58) RXRARXRBALDH1A1ERN1HSD17B10
SCHEMBL2558001 0.81 AURKA (0.55) ALDH1A1TRIM24TRIM33HCAR1ERN1
SCHEMBL17049784 0.80 TRIM24 (0.61) RXRARXRBALDH1A1TRIM24TRIM33
SCHEMBL14565866 0.80 ALDH1A1 (0.76) RXRARXRBALDH1A1TRIM24TRIM33
SCHEMBL16102962 0.80 ALDH1A1 (0.76) RXRARXRBALDH1A1TRIM24TRIM33
SCHEMBL14565804 0.80 ALDH1A1 (0.76) RXRARXRBALDH1A1TRIM24TRIM33
SCHEMBL2559811 0.80 ALDH1A1 (0.53) RXRARXRBALDH1A1TRIM24TRIM33
SCHEMBL15333055 0.80 ALDH1A1 (0.53) ALDH1A1TRIM24TRIM33HCAR1ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed