Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.39 |
| ▸ | CD44 | P16070 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13034112 | 0.95 | PNMT (0.38) | PNMTCD44MAOBHTR2CHTR2B | |
| SCHEMBL588622 | 0.89 | PNMT (0.52) | PNMTCD44MAOBHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL15410642 | 0.87 | PNMT (0.50) | PNMTCD44MAOBHTR2CPOLB | |
| Hydrochloric Acid SCHEMBL12985101 | 0.87 | PNMT (0.50) | PNMTCD44MAOBHTR2CPOLB | |
| SCHEMBL18743002 | 0.85 | CD44 (0.44) | PNMTCD44MAOBHTR2CHTR2B | |
| SCHEMBL15943597 | 0.80 | CD44 (0.42) | PNMTCD44MAOBHTR2CHTR2B | |
| 6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine SCHEMBL29617701 | 0.78 | — | — | |
| 6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine SCHEMBL103669 | 0.78 | — | — | |
| SCHEMBL30331914 | 0.77 | PNMT (0.52) | PNMTCD44MAOBHTR2CHTR2B | |
| SCHEMBL12822 | 0.77 | PNMT (0.52) | PNMTCD44MAOBHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558462-A1 | PYRIDYL-VINYL PYRAZOLOQUINOLINES AS PAR1 INHIBITORS | SANOFI (FR) | 2013-02-20 | — | — | EP | claimed |
| US-20130040981-A1 | Pyridylvinylpyrazoloquinolines as PAR1 inhibitors | SANOFI (FR) | 2013-02-14 | — | — | US | claimed |
| WO-2011128420-A1 | PYRIDYL-VINYL PYRAZOLOQUINOLINES AS PAR1 INHIBITORS | SANOFI (FR) | 2011-10-20 | — | — | WO | claimed |
| US-12157726-B2 | P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof | SHANGHAI ZHIMENG BIOPHARMA INC. | 2024-12-03 | — | — | US | disclosed |
| EP-3798220-B1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | SHANGHAI ZHIMENG BIOPHARMA INC (CN) | 2023-08-23 | — | — | EP | disclosed |
| EP-3798220-B1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | SHANGHAI ZHIMENG BIOPHARMA INC (CN) | 2023-08-23 | — | — | EP | disclosed |
| US-20220402917-A1 | COMPOUND AS SMALL MOLECULE INHIBITOR PD-1/PD-L1 AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2022-12-22 | — | — | US | disclosed |
| US-20220227721-A1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | SHANGHAI ZHIMENG BIOPHARMA INC. (CN) | 2022-07-21 | — | — | US | disclosed |
| US-11365181-B2 | P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof | SHANGHAI ZHIMENG BIOPHARMA INC. (CN) | 2022-06-21 | — | — | US | disclosed |
| US-11365181-B2 | P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof | SHANGHAI ZHIMENG BIOPHARMA INC. (CN) | 2022-06-21 | — | — | US | disclosed |
| US-11312668-B2 | Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose | ABBVIE INC. (US) | 2022-04-26 | — | — | US | disclosed |
| US-20200048394-A1 | HARDENABLE POLYMER COMPOSITION | BASF SE (DE) | 2020-02-13 | — | — | US | disclosed |
| US-20200048431-A1 | STABILIZER COMPOSITION | BASF SE (DE) | 2020-02-13 | — | — | US | disclosed |
| US-20190210954-A1 | Process for Preparing Substituted Biphenyls | LIANHE CHEMICAL TECHNOLOGY CO., LTD (CN) | 2019-07-11 | — | — | US | disclosed |
| US-20170217850-A1 | ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE | ABBVIE INC. | 2017-08-03 | — | — | US | disclosed |
| US-20170217850-A1 | ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE | ABBVIE INC. | 2017-08-03 | — | — | US | disclosed |
| US-8791133-B2 | Pyridylvinylpyrazoloquinolines as PAR1 inhibitors | SANOFI (FR) | 2014-07-29 | — | — | US | disclosed |
| EP-2558462-A1 | PYRIDYL-VINYL PYRAZOLOQUINOLINES AS PAR1 INHIBITORS | SANOFI (FR) | 2013-02-20 | — | — | EP | disclosed |
| US-20130040981-A1 | Pyridylvinylpyrazoloquinolines as PAR1 inhibitors | SANOFI (FR) | 2013-02-14 | — | — | US | disclosed |
| WO-2011128420-A1 | PYRIDYL-VINYL PYRAZOLOQUINOLINES AS PAR1 INHIBITORS | SANOFI (FR) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12157726-B2 | P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof | KCNJ2, KCNN2, KCNH2 | PNMT 149/4885CD44 3506/4885MAOB 1320/4885 |
| US-20190210954-A1 | Process for Preparing Substituted Biphenyls | PIK3CA, PIK3CB, PIK3CG | PNMT 732/4885CD44 4145/4885MAOB 1285/4885 |
| US-20220402917-A1 | COMPOUND AS SMALL MOLECULE INHIBITOR PD-1/PD-L1 AND APPLICATION THEREOF | CD274, PDCD1, PDCD1LG2 | PNMT 4035/4885CD44 620/4885MAOB 2716/4885 |
| US-20220227721-A1 | P-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | KCNJ2, KCNN2, KCNH2 | PNMT 149/4885CD44 3506/4885MAOB 1320/4885 |
| US-11365181-B2 | P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof | KCNJ2, KCNN2, KCNH2 | PNMT 146/4885CD44 3559/4885MAOB 1329/4885 |
| US-20130040981-A1 | Pyridylvinylpyrazoloquinolines as PAR1 inhibitors | F2R, F2RL1, F2RL3 | PNMT 1961/4885CD44 4864/4885MAOB 758/4885 |
| US-20170217850-A1 | ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE | LIPA, ALG1, CEL | PNMT 1202/4885CD44 645/4885MAOB 791/4885 |
| US-11312668-B2 | Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose | LIPA, ALG1, CEL | PNMT 1202/4885CD44 645/4885MAOB 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.