Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | PHGDH | O43175 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31696760 | 0.84 | MAPT (0.47) | LMNAKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL23329066 | 0.82 | TMEM97 (0.44) | DHODHPHGDHLMNAKDM4EMEN1 | |
| SCHEMBL21927844 | 0.82 | PHGDH (0.42) | DHODHPHGDHLMNAKDM4EMEN1 | |
| SCHEMBL15823564 | 0.80 | SCN4A (0.44) | PHGDHLMNAKDM4EMEN1NPC1 | |
| SCHEMBL16347107 | 0.79 | KMT2A (0.48) | PHGDHKDM4ENPC1RAB9AKMT2A | |
| SCHEMBL4692313 | 0.76 | PTPN1 (0.56) | PHGDHPPARGPPARDPPARAUSP2 | |
| SCHEMBL9258776 | 0.72 | KEAP1 (0.66) | DHODHLMNAKDM4ENPC1RAB9A | |
| SCHEMBL19203749 | 0.70 | MAPT (0.48) | LMNAKDM4EMEN1NPC1RAB9A | |
| SCHEMBL16347029 | 0.70 | NPC1 (0.49) | KDM4ENPC1ALDH1A1NFKB1RAB9A | |
| SCHEMBL19209832 | 0.70 | ALDH1A1 (0.32) | LMNAKDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558577-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | Nuevolution A/S (DK) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011127933-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2011-10-20 | — | — | WO | disclosed |