SCHEMBL2557565

SCHEMBL2557565

COc1ccc(O)c(-c2nc(C=O)c[nH]2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GUSB P08236 1/20 0.48
ERN1 O75460 1/20 0.48
GAA P10253 5/20 0.46
MGAM O43451 1/20 0.46
SI P14410 1/20 0.46
MGAM2 Q2M2H8 1/20 0.46
NPC1 O15118 5/20 0.46
GRK6 P43250 1/20 0.46
TRIM24 O15164 1/20 0.44
TYR P14679 1/20 0.44
TRIM33 Q9UPN9 1/20 0.44
F2 P00734 1/20 0.43
F10 P00742 1/20 0.43
PLG P00747 1/20 0.43
PLAU P00749 1/20 0.43
PLAT P00750 1/20 0.43
PRSS1 P07477 1/20 0.43
MEN1 O00255 4/20 0.42
ALOX15 P16050 4/20 0.42
KMT2A Q03164 4/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15330573 0.90 TRIM24 (0.49) GUSBERN1GAAMGAMSI
SCHEMBL2557528 0.85 KDM4E (0.44) MAPTKDM4EHPGDSMN1; SMN2ALDH1A1
SCHEMBL2550228 0.85 GRK6 (0.44) ERN1NPC1GRK6MAPTRAB9A
SCHEMBL2555864 0.83 PIK3CA (0.39) GUSBGAANPC1KMT2ARAB9A
SCHEMBL2554665 0.82 ALDH1A1 (0.46) ERN1GAAMAPTKDM4EHPGD
SCHEMBL2556126 0.81 AMY1A (0.51) ERN1GRK6MAPTKDM4EALDH1A1
SCHEMBL31429583 0.80 GAA (0.53) GUSBGAAMGAMSIMGAM2
SCHEMBL2560428 0.80 IDO1 (0.45) NPC1F2F10PLGPLAU
SCHEMBL15331999 0.79 IDO1 (0.44) ERN1GAAMGAMSIMGAM2
SCHEMBL2558280 0.79 IDO1 (0.47) GUSBERN1MEN1ALOX15KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed