SCHEMBL2558280

SCHEMBL2558280

O=Cc1c[nH]c(-c2cc(Cl)ccc2O)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 5/20 0.47
ERN1 O75460 1/20 0.44
PIM1 P11309 2/20 0.42
HDAC6 Q9UBN7 1/20 0.41
EPHX2 P34913 1/20 0.38
EEF2K O00418 1/20 0.37
PLK4 O00444 1/20 0.37
IKBKB O14920 1/20 0.37
DYRK3 O43781 1/20 0.37
CDK2 P24941 1/20 0.37
AKT1 P31749 1/20 0.37
AKT2 P31751 1/20 0.37
CLK2 P49760 1/20 0.37
GSK3B P49841 1/20 0.37
IRAK1 P51617 1/20 0.37
RPS6KA3 P51812 1/20 0.37
NEK4 P51957 1/20 0.37
PLK1 P53350 1/20 0.37
CSNK2A1 P68400 1/20 0.37
CDK5 Q00535 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2560847 0.85 ALDH1A1 (0.46) IDO1MAPTALDH1A1AGPAT2
SCHEMBL2560428 0.84 IDO1 (0.45) IDO1HDAC6CLK2DYRK1ACLK4
SCHEMBL15331999 0.82 IDO1 (0.44) IDO1ERN1PIM1MEN1KMT2A
SCHEMBL2552687 0.82 ALDH1A1 (0.45) MEN1KMT2AHPGDLMNAMAPT
SCHEMBL15330744 0.81 HTR2B (0.51) IDO1MEN1KMT2AKDM4EHPGD
SCHEMBL2557565 0.79 GUSB (0.48) ERN1MEN1KMT2AKDM4EHPGD
SCHEMBL2553963 0.79 AMY1A (0.41) IDO1MEN1KMT2AALDH1A1HTT
SCHEMBL15332170 0.78 ERN1 (0.52) ERN1MEN1KMT2AKDM4EHPGD
SCHEMBL15333376 0.78 IDO1 (0.39) IDO1ERN1MEN1KMT2AKDM4E
SCHEMBL29952752 0.78 IDO1 (0.39) IDO1ERN1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed