Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25576017 | 0.96 | NAAA (0.52) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL24620722 | 0.95 | NAAA (0.55) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL19747788 | 0.87 | MEN1 (0.53) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL17652562 | 0.86 | HDAC1 (0.54) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL19747112 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL17661235 | 0.85 | HDAC1 (0.49) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL17874030 | 0.84 | MAPT (0.56) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL17652621 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL17652550 | 0.84 | MEN1 (0.55) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL13901842 | 0.84 | FAAH (0.61) | SMN1; SMN2RAB9AMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472156-B1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |