Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6112537 | 0.90 | PDE10A (0.61) | PDE10AHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8272011 | 0.88 | PDE10A (0.62) | PDE10AKDM4EALDH1A1LMNANPC1 | |
| SCHEMBL8271489 | 0.85 | PDE10A (0.63) | PDE10ASMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL8271479 | 0.84 | PDE10A (0.66) | PDE10AKDM4EALDH1A1LMNANPC1 | |
| SCHEMBL8271493 | 0.82 | PDE10A (0.65) | PDE10AHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8272634 | 0.80 | PDE10A (0.64) | PDE10AHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7705223 | 0.80 | PDE10A (0.59) | PDE10AHTTKDM4EALDH1A1LMNA | |
| SCHEMBL2563176 | 0.80 | PDE10A (0.57) | PDE10AHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8271478 | 0.80 | PDE10A (0.63) | PDE10AKDM4EALDH1A1LMNANPC1 | |
| SCHEMBL8272031 | 0.79 | PDE10A (0.59) | PDE10AKDM4EALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |